Stamik-500

Stamik-500 Injection is a high-quality antibiotic formulation manufactured by Amista Labs, designed for the effective management of serious bacterial infections. This injectable preparation contains Amikacin, a well-established aminoglycoside antibiotic known for its broad-spectrum activity against a wide range of gram-negative and certain gram-positive bacteria. Stamik-500 Injection is formulated for intravenous (IV) or intramuscular (IM) use only, ensuring rapid onset of action in acute and severe infections.

Composition & Formulation

Each 2 ml vial of Stamik-500 Injection contains:

• Amikacin 500 mg

• Methyl Paraben 0.18% w/v (as preservative)

• Propyl Paraben 0.02% w/v (as preservative)

The therapeutic efficacy of Stamik-500 is derived from its precise chemical composition:

• Active Ingredient: Amikacin Sulfate (equivalent to 500mg Amikacin per 2ml).

• Preservatives: * Methyl Paraben (0.18% w/v): Added to prevent microbial growth and maintain the sterility of the solution.

  • Propyl Paraben (0.02% w/v): Works synergistically with Methyl Paraben to extend the product’s shelf life and stability.

Mechanism of Action

Amikacin works by binding to the bacterial 30S ribosomal subunit, which is essential for protein synthesis. By attaching to this site, Stamik-500 causes a misreading of the genetic code, leading to the production of non-functional proteins or the complete inhibition of protein synthesis. This results in the death of the bacteria, classifying Amikacin as a bactericidal agent.

Unlike many other aminoglycosides, Amikacin is uniquely resistant to most aminoglycoside-modifying enzymes, allowing it to remain effective against strains that are resistant to Gentamicin or Tobramycin.

Clinical Applications

Stamik-500 is reserved for severe infections. Its primary indications include:

1. Nosocomial Infections: Often used for hospital-acquired pneumonia or bloodstream infections (sepsis) caused by resistant Gram-negative bacilli.

2. Urinary Tract Infections (UTI): Effective in complicated or recurrent UTIs where first-line antibiotics are ineffective.

3. Intra-abdominal Infections: Used in combination with other agents to treat peritonitis or post-surgical infections.

4. Bone and Joint Infections: Treats osteomyelitis caused by susceptible organisms.

5. Meningitis: In specific neonatal or adult cases, it may be used as part of a regimen to treat central nervous system infections.

Administration and Dosage

Stamik-500 is designed for Intramuscular (I.M.) or Intravenous (I.V.) use only.

• Dosage: The standard adult dose is typically $15\text{ mg/kg/day}$, divided into two or three equal doses.

• Monitoring: Because aminoglycosides can be toxic to the kidneys and hearing, doctors often monitor “peak and trough” blood levels to ensure the concentration stays within a safe therapeutic window.

Safety Profile and Precautions

While highly effective, Stamik-500 must be used under strict medical supervision due to potential side effects:

• Nephrotoxicity: It can affect renal function. Patients with pre-existing kidney issues require adjusted dosages and frequent monitoring of serum creatinine levels.

• Ototoxicity: Prolonged use or high doses can lead to hearing loss or balance issues (vestibular damage). This is often irreversible, so monitoring for symptoms like tinnitus is essential.

• Neuromuscular Blockade: It should be used with caution in patients with disorders like Myasthenia Gravis, as it can exacerbate muscle weakness.

Storage Instructions

Stamik-500 Injection should be stored in a cool, dry place away from direct sunlight. The vial should be kept out of reach of children and used only if the solution is clear and free from visible particles.

About Amista Labs

Amista Labs is a pharmaceutical company focused on delivering high-quality healthcare solutions. Through products like Stamik-500, they provide essential anti-infective medications to the market, catering to hospital and clinical needs with a focus on manufacturing integrity and therapeutic reliability.

Disclaimer: This information is for educational and promotional purposes. Stamik-500 is a Schedule H drug and must only be used under the prescription and supervision of a qualified medical professional.