Cefsar 100

Cefsar-100, manufactured and marketed by Amista Labs, is a high-efficacy antibiotic formulation designed specifically for pediatric healthcare. Presented as a dry syrup for oral suspension, Cefsar-100 offers a potent solution for treating a wide range of bacterial infections in children. By combining the broad-spectrum power of a third-generation cephalosporin with a patient-friendly delivery system, Amista Labs ensures that Cefsar-100 meets the rigorous demands of modern pediatric medicine.

The product comes in a comprehensive package that includes the dry powder and a dedicated ampoule of Sterile Water for reconstitution, ensuring maximum stability, hygiene, and ease of administration for parents and caregivers.

Composition & Strength

Cefsar-100 is formulated with Cefpodoxime Proxetil according to Indian Pharmacopoeia (IP) standards.

• Active Ingredient: Cefpodoxime Proxetil (Equivalent to Cefpodoxime)

• Strength: 100mg per 5ml (of the reconstituted suspension).

• Form: Dry Syrup (Oral Suspension).

• Additional Component: Supplied with Sterile Water for Injection (SWFI) for reconstitution.

Cefpodoxime Proxetil is an orally administered prodrug that is absorbed and de-esterified in the intestinal wall to release the active antimicrobial agent, Cefpodoxime. As a third-generation cephalosporin, it is renowned for its stability against beta-lactamase enzymes, which are often produced by resistant bacteria.

Mechanism of Action

Cefsar-100 works as a bactericidal agent. It eliminates bacteria by interfering with the synthesis of the bacterial cell wall. Specifically, Cefpodoxime binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This inhibition prevents the final transpeptidation step of peptidoglycan synthesis, resulting in the weakening and eventual lysis (destruction) of the bacterial cell.

This mechanism makes Cefsar-100 highly effective against both Gram-positive and Gram-negative bacteria, including common pathogens like Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.

Therapeutic Indications

Cefsar-100 is indicated for the treatment of mild to moderate infections caused by susceptible strains of microorganisms. It is widely prescribed by pediatricians for:

1. Upper Respiratory Tract Infections (URTI): Including Pharyngitis (sore throat), Tonsillitis, and Sinusitis.

2. Acute Otitis Media: A very common ear infection in children where fluid becomes trapped behind the eardrum, causing pain and fever.

3. Lower Respiratory Tract Infections (LRTI): Including Community-Acquired Pneumonia and acute bronchitis.

4. Skin and Soft Tissue Infections: Treating bacterial infections of the skin, abscesses, or infected wounds.

5. Urinary Tract Infections (UTI): Simple cystitis and other urinary infections.

The Advantage of Dry Syrup with Sterile Water

One of the key features of the Cefsar-100 packaging by Amista Labs is the inclusion of sterile water.

• Stability: Antibiotics like Cefpodoxime are most stable in dry powder form. Liquid suspensions can degrade over time. By keeping the powder dry until the moment of use, Amista Labs ensures the medicine retains 100% potency.

• Convenience: The accompanying sterile water ampoule eliminates the need for parents to boil and cool water at home, removing the risk of contamination during the mixing process. This ensures the suspension is prepared with pharmaceutical-grade purity.

Dosage and Administration

• Reconstitution: Shake the bottle to loosen the powder. Twist the top off the sterile water ampoule and add the water to the bottle (usually up to the ring mark or as directed). Shake vigorously to ensure a uniform suspension.

• Dosage: The dosage of Cefsar-100 should be determined strictly by a physician based on the child’s body weight and the severity of the infection. The 100mg/5ml strength allows for convenient dosing for children who require a higher concentration than standard 50mg syrups.

• Storage: Once reconstituted, the suspension should typically be stored in a refrigerator (2°C – 8°C) and used within the timeframe specified on the packaging (usually 7 to 14 days).

Why Choose Cefsar-100?

Amista Labs has positioned Cefsar-100 as a premium choice in the pediatric antibiotic segment. The packaging features child-friendly graphics to ease anxiety, and the formulation is typically flavored to mask the bitter taste of the antibiotic, improving compliance among fussy children.

Summary of Benefits:

• High Potency: 100mg strength for effective treatment.

• Broad Spectrum: Covers a wide variety of bacterial pathogens.

• Trusted Manufacturing: Produced by Amista Labs under strict quality control.

• Hygienic: Includes sterile water for safe and easy mixing.