Cefsar 50 DS

Cefsar-50 DS is a high-potency pediatric antibiotic formulation manufactured by Amista Labs. It contains Cefpodoxime Proxetil, a third-generation cephalosporin, designed specifically for oral administration in infants and children. As a “DS” (Dry Syrup/Double Strength) formulation, it provides a concentrated dose of $50\text{ mg}$ per $5\text{ ml}$ after reconstitution, making it an essential tool in pediatric medicine for treating a wide range of bacterial infections.

Composition and Pharmaceutical Class

The active ingredient in Cefsar-50 DS is Cefpodoxime Proxetil IP (equivalent to $50\text{ mg}$ of Cefpodoxime per $5\text{ ml}$ after reconstitution).

Cefpodoxime is classified as a third-generation oral cephalosporin. It is a prodrug that is absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. It works by inhibiting bacterial cell wall synthesis. Specifically, it binds to one or more of the penicillin-binding proteins (PBPs), which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, leading to bacterial lysis and death.

Therapeutic Indications

Cefsar-50 DS is indicated for the treatment of mild to moderate infections caused by susceptible strains of microorganisms. Its broad-spectrum nature makes it effective against both Gram-positive and Gram-negative bacteria. Common pediatric applications include:

• Upper Respiratory Tract Infections (URTI): Including acute otitis media (middle ear infection), sinusitis, and pharyngitis/tonsillitis.
• Lower Respiratory Tract Infections: Such as community-acquired pneumonia and acute bronchitis.
• Urinary Tract Infections (UTI): Effective against common uropathogens like E. coli.
• Skin and Soft Tissue Infections: Treatment of uncomplicated infections of the skin structure.

Reconstitution and Administration

As shown in the product packaging, Cefsar-50 DS is supplied as a Dry Syrup (powder for oral suspension).

• Reconstitution Process: The pack includes Sterile Water for reconstitution. To prepare the suspension, the sterile water should be added to the bottle up to the ring mark or as directed. The bottle must be shaken vigorously to ensure a uniform suspension.
• Dosage: The dosage is typically calculated based on the child’s body weight (e.g., $10\text{ mg/kg/day}$ divided into two doses). It is crucial to follow the pediatrician’s specific instructions.
• Usage Tip: It is recommended to administer Cefpodoxime with food to enhance absorption and bioavailability.

Safety and Precautions

While generally well-tolerated, Cefsar-50 DS should be used with caution under specific circumstances:

• Allergic Reactions: It is contraindicated in children with a known allergy to cephalosporins. Cross-sensitivity with penicillin may occur, so a history of penicillin allergy should be shared with the physician.
• Side Effects: Common side effects are usually gastrointestinal, including diarrhea, nausea, or abdominal pain. In rare cases, diaper rash or fungal infections (thrush) may occur due to the alteration of natural flora.
• Antibiotic Resistance: To prevent the development of drug-resistant bacteria, Cefsar-50 DS should only be used to treat infections that are proven or strongly suspected to be caused by bacteria. The full course must be completed even if the child feels better.

Storage and Handling

• Dry Powder: Store in a cool, dry place away from direct sunlight.
• Reconstituted Suspension: Once mixed with water, the suspension is typically stable for 7 to 10 days when stored in a refrigerator. Any unused portion after the treatment course should be discarded safely.
• Note: Always “Shake Well Before Use” to ensure the medication is evenly distributed in each dose.

Manufacturing Excellence: Amista Labs

Amista Labs is the manufacturer behind this product, ensuring that the formulation meets the Indian Pharmacopoeia (IP) standards. Their focus on pediatric-friendly flavoring and stable dry-syrup technology ensures better patient compliance, which is often a challenge in pediatric antibiotic therapy.