Etoricoxib IP 90mg

Coxita-90 is a prescription pharmaceutical product manufactured by Amista Labs. It belongs to the class of medications known as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), specifically categorized as a selective COX-2 inhibitor. Designed for the management of acute and chronic pain associated with inflammatory conditions, Coxita-90 provides a therapeutic solution for patients requiring effective analgesic and anti-inflammatory intervention.

Pharmaceutical Composition

Each film-coated tablet of Coxita-90 contains:

• Active Ingredient: Etoricoxib IP (Indian Pharmacopoeia) — 90mg.
• Excipients: Included as per pharmacopoeial standards to ensure tablet stability, disintegration, and bioavailability.
• Color: Titanium Dioxide IP is used as a coloring agent for the film coating.

Mechanism of Action: Etoricoxib

Etoricoxib is a second-generation selective cyclooxygenase-2 (COX-2) inhibitor. Unlike traditional NSAIDs (such as aspirin or ibuprofen) that inhibit both COX-1 and COX-2 enzymes, Etoricoxib specifically targets the COX-2 enzyme.

• COX-2 Inhibition: This enzyme is primarily responsible for the synthesis of prostaglandins that mediate inflammation, pain, and fever. By blocking COX-2, Coxita-90 reduces the production of these pro-inflammatory chemicals.
• Gastrointestinal Sparing: Because it does not significantly inhibit the COX-1 enzyme—which is responsible for protecting the stomach lining—selective COX-2 inhibitors like Etoricoxib generally carry a lower risk of gastrointestinal ulcers and bleeding compared to non-selective NSAIDs.

Therapeutic Indications

Coxita-90 is indicated for the symptomatic relief of several conditions characterized by pain and inflammation:

• Osteoarthritis (OA): For the management of chronic joint pain and stiffness.
• Rheumatoid Arthritis (RA): To reduce systemic joint inflammation and improve mobility.
• Ankylosing Spondylitis: For the treatment of pain and inflammation in the spine.
• Acute Gouty Arthritis: To manage the intense pain and swelling during a gout flare-up.
• Post-Operative Dental Pain: Used for short-term management of moderate pain following dental procedures.

Dosage and Administration

The dosage of Coxita-90 must be determined by a healthcare professional based on the specific condition being treated:

• Administration: Tablets should be taken orally. They can be taken with or without food, though onset may be faster if taken on an empty stomach.
• Standard Dosing: While 90mg is a common dose for rheumatoid arthritis and ankylosing spondylitis, clinicians often recommend the lowest effective dose for the shortest duration necessary to minimize cardiovascular risks.

Safety Profile and Precautions

While effective, Coxita-90 requires careful medical supervision:

• Cardiovascular Risk: Selective COX-2 inhibitors may be associated with an increased risk of thrombotic events (e.g., heart attack or stroke). It is generally contraindicated in patients with established ischemic heart disease, peripheral arterial disease, or cerebrovascular disease.
• Hypertension: Etoricoxib can increase blood pressure; therefore, blood pressure monitoring is essential during treatment.
• Renal and Hepatic Function: Patients with significant kidney or liver impairment should use this medication with caution and may require dose adjustments.

Packaging and Storage

As seen in the provided image, Coxita-90 is packaged in a professional white and maroon box.

• Configuration: The standard pack contains 10 x 10 tablets in blister strips, ensuring hygiene and moisture protection.
• Storage: Should be stored in a cool, dry, and dark place. Protect from direct light and moisture to maintain the integrity of the active ingredient.
• Safety Warning: Keep out of reach of children.

About the Manufacturer: Amista Labs

Amista Labs is the pharmaceutical entity behind Coxita-90. The company focuses on providing high-quality, affordable healthcare solutions. Their manufacturing processes typically adhere to Good Manufacturing Practices (GMP) and ISO standards, ensuring that products like Coxita-90 meet rigorous safety and efficacy benchmarks required for the Indian and international markets.