Coxita-TH

Coxita-TH Tablets, manufactured by Amista Labs, are a powerful combination therapy designed to provide effective relief from pain, inflammation, and muscle spasms. This formulation combines Etoricoxib IP 60 mg, a selective COX-2 inhibitor, with Thiocolchicoside IP 4 mg, a well-known muscle relaxant. Together, these ingredients offer targeted action for managing acute and chronic musculoskeletal conditions, helping patients regain mobility and comfort quickly.

Understanding the Composition

Coxita-TH is a fixed-dose combination (FDC) medication. To understand its efficacy, it is essential to look at its two active ingredients individually and how they synergize.

1. Etoricoxib IP (60mg)

Etoricoxib belongs to a class of medications known as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Specifically, it is a selective COX-2 inhibitor.

• How it works: Traditional NSAIDs inhibit both COX-1 and COX-2 enzymes. While this reduces pain, blocking COX-1 can often lead to gastrointestinal side effects like ulcers. Etoricoxib selectively targets the COX-2 enzyme, which is responsible for pain and inflammation, while largely sparing the COX-1 enzyme that protects the stomach lining.

• Benefits: This selectivity makes Etoricoxib highly effective for reducing pain, swelling, and redness associated with joint disorders, with a generally lower risk of stomach upset compared to older NSAIDs. At 60mg, it provides a therapeutic dose suitable for managing moderate to severe pain.

2. Thiocolchicoside IP (4mg)

Thiocolchicoside is a semi-synthetic derivative of the naturally occurring compound colchicoside. It functions as a potent muscle relaxant.

• How it works: It acts on the central nervous system (CNS) by binding to GABA-A and glycine receptors. By modulating these receptors, it interrupts the pathway of pain signals in the spinal cord and brain that cause muscles to contract involuntarily.

• Benefits: It effectively relieves muscle stiffness and spasms without causing significant sedation, which is a common side effect of many other muscle relaxants. This allows patients to maintain mobility and continue with their daily activities while recovering.

Therapeutic Indications

The combination of an analgesic (painkiller) and a muscle relaxant makes Coxita-TH highly versatile. It is typically prescribed for conditions where pain is exacerbated by muscle tightening. Common indications include:

• Osteoarthritis & Rheumatoid Arthritis: Helps alleviate the chronic joint pain and inflammation associated with degenerative bone diseases.

• Ankylosing Spondylitis: Useful for pain and stiffness in the spine.

• Low Back Pain: Highly effective for acute lower back pain, which is often accompanied by severe muscle spasms.

• Post-Operative Pain: Can be used to manage pain and stiffness following orthopedic surgeries.

• Sports Injuries: beneficial for sprains, strains, and traumatic injuries where muscle guarding occurs.

Mechanism of Action: The Synergistic Effect

Pain in orthopedic conditions is rarely just about inflammation; it often involves a “pain-spasm-pain” cycle. When a joint or tissue is inflamed (treated by Etoricoxib), the surrounding muscles often contract protectively, leading to spasms (treated by Thiocolchicoside). These spasms cause further pain, which causes more inflammation.

Coxita-TH breaks this cycle by attacking it from both ends:

1. Etoricoxib reduces the chemical messengers (prostaglandins) that cause the initial pain and swelling.

2. Thiocolchicoside relaxes the tight muscles, improving range of motion and reducing the mechanical stress on the affected area.

Dosage and Administration

• Dosage: As directed by a registered medical practitioner. The typical dosage is often one tablet taken daily or twice daily depending on the severity of the condition.

• Administration: The tablet should be swallowed whole with a glass of water. It can be taken with or without food, though taking it with food may further reduce the risk of gastric discomfort.

Why Choose Amista Labs?

Amista Labs ensures that Coxita-TH is manufactured under strict quality control standards (GMP/WHO guidelines). The packaging, as seen in the product image, is designed to protect the integrity of the medication, ensuring that every tablet delivers the precise composition of 60mg Etoricoxib and 4mg Thiocolchicoside for maximum efficacy.

Safety Information & Precautions

• Consult a Doctor: This is a prescription-only medicine (Schedule H). Do not self-medicate.

• Pregnancy/Breastfeeding: Consult a physician before use, as it may not be suitable for pregnant or breastfeeding women.

• Side Effects: While generally well-tolerated, some users may experience mild nausea, dizziness, or indigestion. If symptoms persist, medical advice should be sought immediately.